Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow
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- 阿部, 真也
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University; Graduate School of Medicine, Kyoto University
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- 旭, 拓真
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University; Graduate School of Medicine, Kyoto University
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- 原, 崇裕
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University
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- 崔, 広為
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University
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- 榛葉, 旭恒
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University
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- 谷一, 靖江
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University
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- 山田, 浩平
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University; Graduate School of Biostudies, Kyoto University
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- 宮崎, 和子
- Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University
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- 宮地, 均
- Reproductive Engineering Team, Institute for Life and Medical Sciences, Kyoto University
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- 北野, さつき
- Reproductive Engineering Team, Institute for Life and Medical Sciences, Kyoto University
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- 中村, 直俊
- Interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University
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- 菊田, 順一
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, WPI Immunology Frontier Research Center, Osaka University
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- Vandenbon, Alexis
- Laboratory of Tissue Homeostasis, Department of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University
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- 宮崎, 正輝
- Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University
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- 山田, 亮
- Statistical Genetics, Center for Genomic Medicine, Graduate School of Medicine, Kyoto University
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- 樗木, 俊聡
- Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University
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- 石井, 優
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, WPI Immunology Frontier Research Center, Osaka University
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- Sexl, Veronika
- Institute of Pharmacology and Toxicology, Department for Biomedical Sciences, University of Veterinary Medicine Vienna; Present address: University of Innsbruck
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- 長澤, 丘司
- Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
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- 生田, 宏一
- Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University
説明
Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent manner, the cellular source of IL-15 remains elusive. Using NK cell reporter mice, we show that NK cells are localized in the BM in scattered and clustered manners. NK cell clusters overlap with monocyte and dendritic cell accumulations, whereas scattered NK cells require CXCR4 signaling. Using cell-specific IL-15-deficient mice, we show that hematopoietic cells, but not stromal cells, support NK cell development in the BM through IL-15. In particular, IL-15 produced by monocytes and dendritic cells appears to contribute to NK cell development. These results demonstrate that hematopoietic cells are the IL-15 niche for NK cell development in the BM and that BM NK cells are present in scattered and clustered compartments by different mechanisms, suggesting their distinct functions in the immune response.
収録刊行物
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- Cell Reports
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Cell Reports 42 (9), 2023-09-26
Elsevier BV
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キーワード
詳細情報 詳細情報について
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- CRID
- 1050860609169545216
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- ISSN
- 22111247
- 26391856
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- HANDLE
- 2433/285242
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB