Synthesis of Glycopolymers Carrying 3’-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E
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- Ishida, Takato
- Department of Chemical Engineering, Kyushu University
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- Nagao, Masanori
- Department of Chemical Engineering, Kyushu University
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- Oh, Takahiro
- Department of Chemical Engineering, Kyushu University
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- Mori, Takeshi
- Department of Applied Chemistry, Kyushu University
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- Hoshino, Yu
- Department of Chemical Engineering, Kyushu University
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- Miura, Yoshiko
- Department of Chemical Engineering, Kyushu University
Bibliographic Information
- Other Title
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- Synthesis of Glycopolymers Carrying 3′-Sialyllactose for Suppressing Inflammatory Reaction <i>via</i> Siglec-E
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Description
One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).
Journal
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- Chemistry Letters
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Chemistry Letters 51 (3), 308-311, 2022-01-21
The Chemistry Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1050861482656913920
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- NII Book ID
- AA00603318
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- ISSN
- 13480715
- 03667022
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- HANDLE
- 2324/4793646
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- KAKEN
- OpenAIRE