Synthesis of Glycopolymers Carrying 3’-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E

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  • Synthesis of Glycopolymers Carrying 3′-Sialyllactose for Suppressing Inflammatory Reaction <i>via</i> Siglec-E

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One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).

Journal

  • Chemistry Letters

    Chemistry Letters 51 (3), 308-311, 2022-01-21

    The Chemistry Society of Japan

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