Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways

HANDLE オープンアクセス

抄録

Hepatitis C virus (HCV) is a positive-sense, single-stranded RNA virus that causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The release of infectious HCV particles from infected hepatocytes is a crucial step in viral dissemination and disease progression. While the exact mechanisms of HCV particle release remain poorly understood, emerging evidence suggests that HCV utilizes intracellular membrane trafficking and secretory pathways. These pathways include the Golgi secretory pathway and the endosomal trafficking pathways, such as the recycling endosome pathway and the endosomal sorting complex required for transport (ESCRT)-dependent multivesicular bodies (MVBs) pathway. This review provides an overview of recent advances in understanding the release of infectious HCV particles, with a particular focus on the involvement of the host cell factors that participate in HCV particle release. By summarizing the current knowledge in this area, this review aims to contribute to a better understanding of endosomal pathways involved in the extracellular release of HCV particles and the development of novel antiviral strategies.

収録刊行物

  • Viruses

    Viruses 15 (12), 2430-, 2023-12

    MDPI

キーワード

詳細情報 詳細情報について

  • CRID
    1050861925321824256
  • ISSN
    19994915
  • HANDLE
    20.500.14094/0100486178
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB

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