Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model

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  • 村田, 梢
    Clinical Translational Research Program, RIKEN Center for Biosystems Dynamics Research; Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
  • 牧野, 晶子
    Laboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University
  • 朝長, 啓造
    Laboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University
  • 升本, 英利
    Clinical Translational Research Program, RIKEN Center for Biosystems Dynamics Research; Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

書誌事項

公開日
2024-01-19
資源種別
journal article
権利情報
  • © 2023 The Authors.
  • This is an open access article under the CC BY license.
DOI
  • 10.1016/j.isci.2023.108641
公開者
Elsevier BV

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説明

Patients with chronic cardiomyopathy may have persistent viral infections in their hearts, particularly with SARS-CoV-2, which targets the ACE2 receptor highly expressed in human hearts. This raises concerns about a potential global heart failure pandemic stemming from COVID-19, an SARS-CoV-2 pandemic in near future. Although faced with this healthcare caveat, there is limited research on persistent viral heart infections, and no models have been established. In this study, we created an SARS-CoV-2 persistent infection model using human iPS cell-derived cardiac microtissues (CMTs). Mild infections sustained viral presence without significant dysfunction for a month, indicating persistent infection. However, when exposed to hypoxic conditions mimicking ischemic heart diseases, cardiac function deteriorated alongside intracellular SARS-CoV-2 reactivation in cardiomyocytes and disrupted vascular network formation. This study demonstrates that SARS-CoV-2 persistently infects the heart opportunistically causing cardiac dysfunction triggered by detrimental stimuli such as ischemia, potentially predicting a post COVID-19 era heart failure pandemic.

収録刊行物

  • iScience

    iScience 27 (1), 108641-, 2024-01-19

    Elsevier BV

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