Investigating genetic redundancy as a source of genetic diversity and adaptability in the U.S. Holstein breed
Description
The continuous increase in inbreeding in the U.S. Holstein is a threat to genetic diversity. Loss of genetic diversity can hinder adaptation to changing environments and consumer demands. K-means clustering on the genomic relationship matrix was used to stratify 20,099 selected candidates into five clusters. These clusters were shown to be different through expected inbreeding within- and across cluster, the fixation index (Fst), and genetic correlations for stature between clusters. Expected inbreeding within cluster was mostly higher than across-cluster. The average Fst across cluster was 0.03. Genetic correlations ranged from <0.50 to >0.90. Families were formed by tracing pedigrees of each cluster back for 10 generations. Allele frequency changes over generations were evaluated. Polygenic shifts, selective sweeps, hitch-hiking, and epistasis were observed. The Replicate Frequency Spectrum was used to measure genetic redundancy. Results show that sub-populations within the breed have developed differently over time.
Journal
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- Proceedings of the 12th World Congress of Genetics Applied to Livestock Production
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Proceedings of the 12th World Congress of Genetics Applied to Livestock Production 1000-1003, 2022
Wageningen Academic Publishers
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Details 詳細情報について
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- CRID
- 1050862623748297088
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- HANDLE
- 10659/0002000231
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB