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The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity.
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Description
Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-binding lectin (MBL) and the surfactant proteins SP-A/-D. Collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1) and collectin placenta 1 (CL-P1) are the most recently discovered collectins. Although their function is still under investigation, accumulating information suggests that CL-L1, CL-K1 and CL-P1 play important roles in host defense by recognizing a variety of microorganisms and interacting with effector proteins, including complement components. The recent establishment of the existence of CL-K1 in the circulation in form of heteromeric complexes with CL-L1 (known as CL-LK) and its activation of the lectin pathway via MASPs, drew new attention in the complement biology, which was further strengthened by the observed interactions between CL-P1 and CRP-C1q-factor H or properdin. Deficiency of either CL-K1 or MASP-3 has been demonstrated in 3MC syndrome patients with developmental abnormalities, showing that lectin pathway components, regulation and/or activation are essential during the embryonic development; another feature that they most likely share CL-P1. Herein, we discuss the recent characteristics and roles of the collectins CL-L1, CL-K1 and CL-P1 in the complement system, in innate immunity and their possible association with disease development and pathogenesis.
Journal
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- Immunobiology
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Immunobiology 221 (10), 1058-1067, 2016-10-01
Elsevier BV
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Keywords
- Collectins/chemistry
- Complement
- MASP
- Ligands
- Organ Specificity/genetics
- Structure-Activity Relationship
- Genetic
- Innate
- Animals
- Humans
- 3MC syndrome
- Polymorphism
- Complement Activation
- Innate immunity
- Polymorphism, Genetic
- Immunity
- Complement System Proteins/physiology
- Complement System Proteins
- Scavenger receptor
- Collectins
- Immunity, Innate
- Collectin
- Microbes
- Gene Expression Regulation
- Organ Specificity
- Multigene Family
- Embryogenesis
- Collagen
- Disease Susceptibility
Details 詳細情報について
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- CRID
- 1050862721207720320
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- NII Article ID
- 120006325059
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- ISSN
- 01712985
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- PubMed
- 27377710
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE