Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule
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- Watanabe, Kenji
- Laboratory for Chemical Biology, RIKEN Center for Biosystems Dynamics Research
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- Mao, Qiyue
- Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
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- Zhang, Zhouen
- Laboratory for Chemical Biology, RIKEN Center for Biosystems Dynamics Research
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- Hata, Machi
- Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
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- Kodera, Masahito
- Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
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- Kitagishi, Hiroaki
- Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
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- Niwa, Takashi
- Laboratory for Chemical Biology, RIKEN Center for Biosystems Dynamics Research Laboratory for Molecular Transformation Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
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- Hosoya, Takamitsu
- Laboratory for Chemical Biology, RIKEN Center for Biosystems Dynamics Research Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
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Description
In this study, we successfully synthesized a small-sized gold nanocluster (2 nm) coated with homogeneous tripeptides bearing azido and amino groups that enable facile multifunctionalizations. Using sodium phenoxide to reduce tetrachloroauric(III) acid in the presence of the cysteine-containing tripeptide, we efficiently prepared the gold nanoclusters without damaging the azido group. We then utilized this clickable bisreactive nanocluster as a versatile platform for synthesizing multifunctionalized gold nanomaterials. The resulting nanoclusters were conjugated with an anticancer compound connected to an indolizine moiety for photoinduced uncaging, a photodynamic therapy agent acting as a photosensitizer for uncaging, and a cyclic RGD peptide. The cytotoxicity of the multifunctionalized gold nanoclusters was demonstrated through red light irradiation of human lung cancer-derived A549 cells treated with the synthesized nanomaterials. The significant cytotoxicity exhibited by the cells underscores the potential utility of this method in advanced cancer therapies.
Journal
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- Chemical Science
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Chemical Science 15 (4), 1402-1408, 2023-12-15
Royal Society of Chemistry (RSC)
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Details 詳細情報について
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- CRID
- 1050862931498642688
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- NII Book ID
- AA12555653
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- ISSN
- 20416539
- 20416520
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- HANDLE
- 2324/7174362
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB