Biological effects of α-TCP/Te-CP cement as a pulp-capping agent

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  • HASEGAWA, TOMOYA
    Department of Endodontics, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
  • KAWAKI, HARUMI
    Department of Oral Biochemistry, Division of Oral Structure, Function, and Development, Asahi University School of Dentistry
  • TANAKA, MASASHI
    Department of Endodontics, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
  • SHINTANI, KOHEI
    Department of Dental Materials Science, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
  • KAMIYA, MASAKO
    Chemistry Laboratory, Department of Management and Information studies, Asahi University School of Business Administration
  • TAKAYAMA, EIJI
    Department of Oral Biochemistry, Division of Oral Structure, Function, and Development, Asahi University School of Dentistry
  • KONDO, NOBUO
    Chemistry Laboratory, Asahi University School of Dentistry
  • YOSHIDA, TAKAKAZU
    Asahi University
  • KAWANO, SATOSHI
    Department of Endodontics, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
  • DOI, YUTAKA
    Asahi University

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Abstract

In this study, we investigated the affinity of our calcium phosphate cements to dental pulp cells. The cement was mainly composed of α-TCP and Te-CP, prepared by a one-step sintering method and mixed with three different aqueous solutions. Three types of α-TCP/Te-CP cements, each with 1 M or 2 M sodium dihydrogen phosphate, or 1 M citric acid, and calcium hydroxide agent were evaluated. First, dental pulp cells were cultured in a medium containing components leached from the cements, and we found that our all three types of α-TCP /Te-CP cement did not inhibit cell proliferation and showed no significant cytotoxicity compared to the calcium hydroxide cement. In vivo evaluation was then performed using a pulp-exposed animal model. The α-TCP /Te-CP cement prepared with 2M sodium dihydrogen phosphate showed remarkable pulpal tissue affinity. These results suggested that the newly developed α-TCP /Te-CP material could be a promising pulp capping material.

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