Current Status of Cancer Genomic Profiling Test in Shinshu University Hospital

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  • MIYAGAWA Mariko
    Shinshu Cancer Center, Shinshu University Hospital Department of Nursing, Shinshu University Hospital
  • KANDA Shintaro
    Shinshu Cancer Center, Shinshu University Hospital
  • SHIGETO Shohei
    Department of Laboratory Medicine, Shinshu University Hospital
  • NAKAJIMA Tomoyuki
    Department of Laboratory Medicine, Shinshu University Hospital
  • YAMAZAKI Yayoi
    Department of Laboratory Medicine, Shinshu University Hospital
  • TAMADA Hisashi
    Department of Laboratory Medicine, Shinshu University Hospital
  • ASAKA Shiho
    Department of Laboratory Medicine, Shinshu University Hospital Department of Laboratory Medicine, Nagano Children's Hospital
  • UEHARA Takeshi
    Department of Laboratory Medicine, Shinshu University Hospital
  • TATEISHI Ayako
    Department of Pathology, Shinshu University School of Medicine
  • WATANABE Hiroaki
    Department of Pharmacy, Shinshu University Hospital
  • MOMOSE Hanako
    Shinshu Cancer Center, Shinshu University Hospital Department of Nursing, Shinshu University Hospital
  • TOKORO Mayumi
    Shinshu Cancer Center, Shinshu University Hospital Department of Nursing, Shinshu University Hospital
  • KOJIMA Tomomi
    Center for Medical Genetics, Shinshu University Hospital
  • NAGAI So
    Center for Medical Genetics, Shinshu University Hospital Department of Medical Genetics, Shinshu University School of Medicine Division of Clinical Sequencing, Shinshu University School of Medicine
  • TAKANO Kyoko
    Center for Medical Genetics, Shinshu University Hospital Department of Medical Genetics, Shinshu University School of Medicine
  • KOSHO Tomoki
    Center for Medical Genetics, Shinshu University Hospital Department of Medical Genetics, Shinshu University School of Medicine Division of Clinical Sequencing, Shinshu University School of Medicine
  • KOIZUMI Tomonobu
    Shinshu Cancer Center, Shinshu University Hospital

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  • 信州大学医学部附属病院におけるがんゲノムプロファイリング検査の現状
  • シンシュウ ダイガク イガクブ フゾク ビョウイン ニ オケル ガン ゲノムプロファイリング ケンサ ノ ゲンジョウ

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Introduction : Comprehensive Cancer Genomic Profiling Tests (CGP) were approved for Japanese health insurance in June 2019. Shinshu University Hospital is designated as a cancer genome hub hospital and has the function to conduct CGP and expert panel to assign clinical meaning to the results.<br>Material and methods : We retrospectively analyzed the data of CGP and the expert panel in Shinshu University Hospital and the liaison hospitals in Nagano prefecture from January 2020 to December 2022.<br>Results : A total of 296 patients (mean age 60.0 years, men/female 127/169) received CGP in our hospital. 90, 164, and 41 patients received NCC Oncopanel System, FoundationOne® CDx, and FoundationOne® Liquid CDx, respectively. We could present genetically compatible treatments based on the CGP test to 43 cases (14.5％). 14 cases have been found to have presumed germline pathogenic variants, and 10 cases among them were received genetic counseling.<br>Conclusion : The number of cancer patients receiving CGP in our hospital or Nagano Prefecture is increasing. But there are several issues to be addressed, such as conducting the clinical studies in our institution to increase the patients who can reach to the new adequate treatment.

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