Sleep quality and temperament in association with autism spectrum disorder among infants in Japan

IR (HANDLE) Open Access
  • Kikuchi, Kimiyo
    Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University
  • Michikawa, Takehiro
    Department of Environmental and Occupational Health, School of Medicine, Toho University
  • Morokuma, Seiichi
    Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University Research Center for Environment and Developmental Medical Sciences, Kyushu University
  • Hamada, Norio
    Research Center for Environment and Developmental Medical Sciences, Kyushu University Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Suetsugu, Yoshiko
    Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University
  • Ikeda, Subaru
    Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University
  • Nakahara, Kazushige
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Kato, Kiyoko
    Research Center for Environment and Developmental Medical Sciences, Kyushu University Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Ochiai, Masayuki
    Research Center for Environment and Developmental Medical Sciences, Kyushu University Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
  • Shibata, Eiji
    Regional Center for Japan Environment and Children’s Study, University of Occupational and Environmental Health Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health
  • Tsuji, Mayumi
    Regional Center for Japan Environment and Children’s Study, University of Occupational and Environmental Health Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
  • Shimono, Masayuki
    Regional Center for Japan Environment and Children’s Study, University of Occupational and Environmental Health Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
  • Kawamoto, Toshihiro
    Regional Center for Japan Environment and Children’s Study, University of Occupational and Environmental Health
  • Ohga, Shouichi
    Research Center for Environment and Developmental Medical Sciences, Kyushu University Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
  • The Japan Environment and Children’s Study Group
  • Kusuhara, Koichi
    Regional Center for Japan Environment and Children’s Study, University of Occupational and Environmental Health Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
  • Kamijima, Michihiro
    Nagoya City University
  • Yamazaki, Shin
    National Institute for Environmental Studies
  • Ohya, Yukihiro
    National Center for Child Health and Development
  • Kishi, Reiko
    Hokkaido University
  • Yaegashi, Nobuo
    Tohoku University
  • Hashimoto, Koichi
    Fukushima Medical University
  • Mori, Chisato
    Chiba University
  • Ito, Shuichi
    Yokohama City University
  • Yamagata, Zentaro
    University of Yamanashi
  • Inadera, Hidekuni
    University of Toyama
  • Nakayama, Takeo
    Kyoto University
  • Iso, Hiroyasu
    Osaka University
  • Shima, Masayuki
    Hyogo College of Medicine
  • Kurozawa, Youichi
    Tottori University
  • Suganuma, Narufumi
    Kochi University
  • Katoh, Takahiko
    Kumamoto University

Description

Background: / Sleep problems and irritable temperaments are common among infants with autism spectrum disorder (ASD). The prospective association between such sleep problems and irritable temperaments and ASDs needs to be determined for elucidating the mechanism and exploring the future intervention study. Thus, in this study, we investigated whether sleep quality and temperament in 1-month-old infants are associated with the onset of ASD in 3-year-old children. We also assessed its sex-stratified associations. / Methods: / We conducted a longitudinal study using data from 69,751 mothers and infants from a large-cohort study, the Japan Environment and Children’s Study. We examined the prospective association between infant sleep quality and temperament at 1 month of age and ASD diagnosis by 3 years of age. / Results: / Here we show infants with longer daytime sleep have a higher risk of later ASD than those with shorter daytime sleep (risk ratio [RR]: 1.33, 95% confidence interval [CI]: 1.01–1.75). Infants who experienced intense crying have a higher risk of ASD than those who did not (RR: 1.31, 95% CI: 1.00–1.72). There is a difference in sex in the association between a bad mood and later ASD. In particular, female infants experiencing bad moods have a higher risk of ASD than others (RR: 3.59, 95% CI: 1.91–6.75). / Conclusions: / The study findings provide important information for future intervention to reduce the risk of future ASD.

Journal

Keywords

Details 詳細情報について

  • CRID
    1050863782913698688
  • ISSN
    2730664X
  • HANDLE
    2324/7183385
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB

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