細菌感染症患者におけるスタチンの多面的効果

Nishitani, Noriko, Fushitani, Syuji, 柴田, 洋文, Takiguchi, Masufumi, 川添, 和義, Yoshihara, Shin’ichi, 水口, 和生

Statins, treatments for dyslipidemia, have been reported to possess effects leading to the repair of the vascular endothelium, as well as anti-oxidative and anti-inflammatory effects, and their clinical usefulness has been focused on. It was also reported in previous clinical research that bacteremia patients on statins showed a lower mortality compared to those not receiving statins, and atherosclerosis patients on statins showed a significantly lower rate of severe or fatal sepsis compared to those not receiving them. We conducted a case-control study involving patients hospitalized in Tokushima University Hospital to evaluate the relationship between taking／not taking statins and bacterial infectious diseases. As a result, there was no relationship between taking／not taking statins and the overall patients with bacterial infectious diseases, but sepsis patients on statins showed a significantly lower mortality. The taking of statins was suggested to be useful for patients with bacterial infectious diseases, particularly males.

細菌感染症患者におけるスタチンの多面的効果

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