人工生体膜のソフトナノテクノロジー

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  • ジンコウ セイタイマク ノ ソフト ナノ テクノロジー
  • Soft Nanotechnology of Artificial Biological Membranes

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Soft nanotechnology is technology that treats soft and wet materials such as self-assembly systems in a living body under a relatively moderate condition. We focus our attention on the size control of liposomes, namely lipid bilayer membranes and performed the soft nanotechnology in sizing of liposomes under high pressure. Two high-pressure sizing techniques, a method of continuous pressure relaxation using a phase transition between gel and liquid crystalline phases of the bilayer membrane and that of a pressure-induced gel phase using a phase transition between bilayer and nonbilayer membranes, were applied to liposomes of distearoylphosphatidylcholine, and the effects of the both methods were considered. Further, the application of giant liposomes controlled by high-pressure sizing to microsensor was briefly described.

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