Comparison of multicolor scanning laser ophthalmoscopy and optical coherence tomography angiography for detection of microaneurysms in diabetic retinopathy

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Bibliographic Information

Title
Comparison of multicolor scanning laser ophthalmoscopy and optical coherence tomography angiography for detection of microaneurysms in diabetic retinopathy
Other Title
  • 共焦点レーザー走査型検眼鏡とOCTAにおける糖尿病網膜症患者の毛細血管瘤の検出率の比較
Author
Sakono, Takato
Alias Name
  • 迫野, 能士
  • サコノ, タカト
University
鹿児島大学
Types of degree
博士(医学)
Grant ID
甲総研第667号
Degree year
2022-08-23

Description

This study aimed to evaluate the usefulness of multicolor (MC) scanning laser ophthalmoscopy (MC-SLO) in detecting microaneurysm (MA) in eyes with diabetic retinopathy (DR). This was a retrospective cross-sectional study. Eyes with DR underwent fluorescein angiography (FA), MC-SLO, optical coherence tomography angiography (OCTA), and color fundus photography (CFP) were analyzed. The foveal region was cut in an 6 × 6 mm image and the number of MA in each image was counted by retina specialists to determine the sensitivity and positive predictive value. FA results were used as the ground standard. MAs were classified as those with early, late, or no dye leakage based on FA images. Fifty-four eyes of 35 patients with an average age of 64.5 ± 1.24 years were included. The sensitivity of MA detection was 37.3%, 15.3%, and 4.12% in MC-SLO, OCTA, and CFP, respectively (P < 0.01 in each pair).The positive predictive value was 66.4%, 46.4%, and 27.6% in MC, OCTA, and CFP, respectively (P < 0.01 in each pair). Sensitivity for MAs with early leakage was 36.4% in MC-SLO, which was significantly higher than 4.02% in OCTA. MC-SLO was more useful in detecting MA in eyes with DR than OCTA. Takato Sakono, Hiroto Terasaki, Shozo Sonoda, Ryoh Funatsu, Hideki Shiihara, Eisuke Uchino, Toshifumi Yamashita & Taiji Sakamoto Comparison of multicolor scanning laser ophthalmoscopy and optical coherence tomography angiography for detection of microaneurysms in diabetic retinopathy Scientific Reports (2021) 11:17017 The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: https://doi.org/10.1038/s41598-021-96371-y

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