Change in neuronal firing patterns in the process of motor command generation for ocular following response

Takemura, Aya

doi:10.11501/3174873

Bibliographic Information

Title: Change in neuronal firing patterns in the process of motor command generation for ocular following response

Other Title

追従眼球運動発現のための情報処理に関与するニューロンの発火パターンの解析

Author: Takemura, Aya

Alias Name

竹村, 文

University: University of Tsukuba

Types of degree: 博士（医学）

Grant ID: 甲第2399号

Degree year: 2000-03-24

Description

We recorded the activity of single neurons in the medial superior temporal (MST) area of the cortex, the dorsolateral pontine nucleus (DLPN), and the ventral paraflocculus (VPFL) of the cerebellum of alert monkeys during ocular following elicited by sudden movements of a large-field pattern. To examine the motor-command generation process for ocular following responses, we quantitatively analyzed the relationship berween neuronal firing frequency in each brain region and eye movement or retinal slip by applying linear-regression models for reconstructing the temporal waveform of firing. The coefficients of acceleration, velocity, position, and bias, in addition to the time lag between firing and eye movement/retinal slip were estimated by the least-square error method. As previously reported, the temporal firing patterns of most Purkinje cells (P cells) in the VPFL were satisfactorily reconstructed from eye movement for each stimulus condition (Local Fitting) and for the variety stimulus conditions (Global Fitting) (17 of 20 P cells). By contrast, only 57% (99/175) and 55% (88/160) of the temporal firing patterns taken from 35 MST and 32 DLPN neurons were satisfactorily reconstructed from eye movement for each stimulus condition. Additionally, for the variety stimulus conditions, the firing patterns of two-thirds of the MST and DLPN neurons (25 of 35 for MST, 22 of 32 for DLPN) were only poorly reconstructed from eye movements with a single set of coefficients. These findings indicate that the eye movements during ocular following are not linearly related to neuronal activity in the MST and DLPN, but are linearly related with those in the VPFL, within the observed stimulus range. However, the temporal firing patterns in the MST and DLPN were satisfactorily reconstructed more often from retinal slips than from eye movement (P < 0.008) for the single stimulus condition. For the variety stimulus conditions, the observed temporal firing patterns of the P cells in the VPFL, DLPN, and MST neurons could not be reconstructed from retinal slips of one parameter set. These observations suggest that neurons in the MST and DLPN play a role in detecting the visual motion signal at the preferred direction and speed of each neuron and that the information of temporal firing patterns of these neurons having a variety of temporal and directional characteristics converge on the P cells in the VPFL. Finally, the temporal firing patterns of the P cells appear to represent the motor command utilized by the downstream structures for eliciting ocular following.

Table of Contents

Contents

Summary

Introduction

Methods

Results

Discussion

Acknowledgment

References

Tables

Figures

追従眼球運動時の3つの脳内領域のニューロン活動の解析

Inverse-Dynamics Representation of Eye Movements by Cerebellar Purkinje Cell Activity during Short-Latency Ocular-Following Responses

Visual inputs to cerebellar ventral paraflocculus during ocular following responses

Temporal Firing Patterns of Purkinje Cells in the Cerebellar Ventral Paraflocculus During Ocular Following Responses in Monkeys I.Simple Spikes

Temporal Firing Patterns of Purkinje Cells in the Cerebellar Ventral Paraflocculus During Ocular Following Responses in Monkeys II. Complex Spikes

A mathematical model that reproduces vertical ocular following responses from visual stimuli by reproducing the simple spike firing frequency of Purkinje cells in the cerebellum

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