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The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of the plasma inorganic phosphate concentration
Bibliographic Information
- Title
- The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of the plasma inorganic phosphate concentration
- Other Title
-
- ナトリウム依存性リン酸トランスポーターとニコチンアミドホスホリボシルトランスフェラーゼは血漿無機リン酸濃度の日内変動に関与する
- Liver-kidney axis and plasma Pi rhythm
- Author
- Miyagawa, Atsumi
- Alias Name
-
- 宮川, 淳美
- ミヤガワ, アツミ
- Author
- Tatsumi, Sawako
- Alias Name
-
- 辰巳, 佐和子
- タツミ, サワコ
- Author
- Takahama, Wako
- Alias Name
-
- タカハマ, ワコ
- タカハマ, ワコ
- Author
- Fujii, Osamu
- Alias Name
-
- フジイ, オサム
- フジイ, オサム
- Author
- Nagamoto, Kenta
- Alias Name
-
- ナガモト, ケンタ
- ナガモト, ケンタ
- Author
- Kinoshita, Emi
- Alias Name
-
- キノシタ, エミ
- キノシタ, エミ
- Author
- Nomura, Kengo
- Alias Name
-
- ノムラ, ケンゴ
- ノムラ, ケンゴ
- Author
- Ikuta, Kayo
- Alias Name
-
- イクタ, カヨ
- イクタ, カヨ
- Author
- Fujii, Toru
- Alias Name
-
- フジイ, トオル
- フジイ, トオル
- Author
- Hanazaki, Ai
- Alias Name
-
- ハナザキ, アイ
- ハナザキ, アイ
- Author
- Kaneko, Ichiro
- Alias Name
-
- 金子, 一郎
- カネコ, イチロウ
- Author
- Segawa, Hiroko
- Alias Name
-
- 瀬川, 博子
- セガワ, ヒロコ
- Author
- Miyamoto, Ken-ichi
- Alias Name
-
- 宮本, 賢一
- ミヤモト, ケンイチ
- University
- 徳島大学
- Types of degree
- 博士（栄養学）
- Grant ID
- 甲栄第247号
- Degree year
- 2018-02-22
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Description
Circulating inorganic phosphate exhibits a remarkable daily oscillation based on food intake. In humans and rodents, the daily oscillation in response to food intake may be coordinated to control the intestinal absorption, renal excretion, cellular shifts, and extracellular concentration of inorganic phosphate. However, mechanisms regulating the resulting oscillation are unknown. Here we investigated the roles of the sodium phosphate cotransporter SLC34 (Npt2) family and nicotinamide phosphoribosyltransferase (Nampt) in the daily oscillation of plasma inorganic phosphate levels. First, it is roughly linked to urinary inorganic phosphate excretion. Second, expression of renal Npt2a and Npt2c, and intestinal Npt2b proteins also exhibit a dynamic daily oscillation. Analyses of Npt2a, Npt2b, and Npt2c knockout mice revealed the importance of renal inorganic phosphate reabsorption and cellular inorganic phosphate shifts in the daily oscillation. Third, experiments in which nicotinamide and a specific Nampt inhibitor (FK866) were administered in the active and rest phases revealed that the Nampt/NAD+ system is involved in renal inorganic phosphate excretion. Additionally, for cellular shifts, liver-specific Nampt deletion disturbed the daily oscillation of plasma phosphate during the rest but not the active phase. In systemic Nampt+/- mice, NAD levels were significantly reduced in the liver, kidney, and intestine, and the daily oscillation (active and rest phases) of the plasma phosphate concentration was attenuated. Thus, the Nampt/ NAD+ system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels.