Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow

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Bibliographic Information

Title
Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow
Other Title
  • ニトログリセリン局所投与における蝸牛血流への影響
Author
ITO, ASAKO
Author
NAKASHIMA, TSUTOMU
Author
YANAGITA, NORIYUKI
Author
伊藤, 麻子
Author
中島, 務
Author
柳田, 則之
University
Nagoya University
Types of degree
博士(医学)
Grant ID
乙第4770号
Degree year
1995-05-01

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Description

Purpose: To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function. Materials and Methods: The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass micro-electrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments. Results: Low doses (0.0001 to 1 wg) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 ILg) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential. Conclusions: Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases.

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