Biocompatibility of titanium surface nanostructures following chemical processing and heat treatment

The aims of the present study were to investigate alkali and heat treatment of titanium surfaces, and to evaluate the ability of such modified surfaces to improve osteogenic differentiation of rat bone marrow (RBM) cells to increase the success rate of titanium implants. To improve bone differentiation on titanium alloy implants, titania nanosheet (TNS) structures were fabricated on titanium surfaces by NaOH and heat treatment at 200, 400, 600, and 800°C. Cell behavior on heat- treated TNS-modified titanium was investigated, and the ability of the modified surfaces to affect osteogenic differentiation of RBM cells and to increase the success rate of titanium implants was evaluated. The nanoscale network structures formed by alkali etching markedly enhanced the cell adhesion and osteogenesis-related gene expression of RBM cells. Other cell behaviors, such as proliferation, alkaline phosphatase activity, osteocalcin deposition, and mineralization, were also markedly increased on heat-treated TNS-modified titanium. Our results suggest that nanostructure-modified titanium implants promote osteogenic differentiation, which may improve biointegration of these implants into alveolar bone.

2017年度

収集根拠 : 博士論文（自動収集）
資料形態 : テキストデータ
コレクション : 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
The aims of the present study were to investigate alkali and heat treatment of titanium surfaces, and to evaluate the ability of such modified surfaces to improve osteogenic differentiation of rat bone marrow (RBM) cells to increase the success rate of titanium implants. To improve bone differentiation on titanium alloy implants, titania nanosheet (TNS) structures were fabricated on titanium surfaces by NaOH and heat treatment at 200, 400, 600, and 800°C. Cell behavior on heat- treated TNS-modified titanium was investigated, and the ability of the modified surfaces to affect osteogenic differentiation of RBM cells and to increase the success rate of titanium implants was evaluated. The nanoscale network structures formed by alkali etching markedly enhanced the cell adhesion and osteogenesis-related gene expression of RBM cells. Other cell behaviors, such as proliferation, alkaline phosphatase activity, osteocalcin deposition, and mineralization, were also markedly increased on heat-treated TNS-modified titanium. Our results suggest that nanostructure-modified titanium implants promote osteogenic differentiation, which may improve biointegration of these implants into alveolar bone.
2017年度