非小細胞肺癌においてHLA Class I H鎖の発現低下は予後不良と相関している

DOI 機関リポジトリ (HANDLE) NDLデジタルコレクション

書誌事項

タイトル
非小細胞肺癌においてHLA Class I H鎖の発現低下は予後不良と相関している
タイトル別名
  • Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer
著者
市之川, 一臣
学位授与大学
北海道大学
取得学位
博士(医学)
学位授与番号
甲第12529号
学位授与年月日
2017-03-23

説明

The aim of this study was to clarify the associations between expression of human leukocyte antigen (HLA) class I on non-small-cell lung cancer (NSCLC) cells, and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival curves were compared using the log-rank test. In addition, multivariate analyses were undertaken using Cox's proportional hazard model. The cases were divided into five classes based on expression of HLA class I heavy chain and β2-microglobulin. Overall survival for patients with tumors lacking HLA class I heavy chain (30 cases; 27.0%) was significantly compromised. Multivariate analysis revealed the absence of HLA class I heavy chain to be an independent predictor of poor prognosis. There was a trend towards unfavorable prognosis for those patients whose tumors did not express β2-microglobulin (57 cases; 51.4%). Down-regulation of HLA class I heavy chain expression significantly correlated with down-regulation of β2-microglobulin expression (χ2; 44 p<0.01). Cases lacking both HLA class I heavy chain and β2-microglobulin expression (23 cases; 20.7%) had a statistically significant unfavorable prognosis compared with other cases (p<0.05). Our data demonstrate that lack of HLA class I heavy chain expression in tumor cells is an independent poor prognostic factor for NSCLC survival, and is likely to have an important influence on immune surveillance in patients.

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ