Pericardial Fat Is Associated With Prevalent Atrial Fibrillation

DOI Web Site 被引用文献17件
  • George Thanassoulis
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Joseph M. Massaro
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Christopher J. O'Donnell
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Udo Hoffmann
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Daniel Levy
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Patrick T. Ellinor
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Thomas J. Wang
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Renate B. Schnabel
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Ramachandran S. Vasan
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Caroline S. Fox
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...
  • Emelia J. Benjamin
    From the Framingham Heart Study (G.T., C.J.O., D.L., R.B.S., R.S.V., C.S.F., E.J.B.), Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham, Mass; Boston University School of Medicine (G.T., E.J.B.), Boston, Mass; Boston University School of Public Health (J.M.M., R.S.V., E.J.B.), Boston, Mass; Massachusetts General Hospital (C.J.O., U.H., P.T.E., T.J.W., C.S.F.), Harvard Medical School, Boston, Mass; MGH PET MR CT Program (U.H.), Boston, Mass;...

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タイトル別名
  • The Framingham Heart Study

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<jats:sec> <jats:title>Background—</jats:title> <jats:p>Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p>Participants from the Framingham Heart Study underwent multidetector computed tomography from 2002 to 2005. We estimated the association between quantitative pericardial, intrathoracic and visceral adipose tissue volumes (per standard deviation of volume) with prevalent AF adjusting for established AF risk factors (age, sex, systolic blood pressure, blood pressure treatment, PR interval, and clinically significant valvular disease). Of the 3217 eligible participants (mean age, 50.6±10.1 years; 48% women), 54 had a confirmed diagnosis of AF. Pericardial fat but not intrathoracic or visceral abdominal fat was associated with prevalent AF in multivariable-adjusted models (odds ratio per standard deviation of pericardial fat volume, 1.28; 95% confidence intervals, 1.03 to 1.58). Further adjustments for body mass index, heart failure, myocardial infarction, and intrathoracic fat volume did not materially change the association between pericardial fat and AF.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>Pericardial fat was associated with prevalent AF even after adjustment for AF risk factors, including body mass index. If this association is replicated, further investigations into the mechanisms linking pericardial fat to AF are merited.</jats:p> </jats:sec>

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