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- Salome Veshaguri
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Sune M. Christensen
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Gerdi C. Kemmer
- Centre for Membrane Pumps in Cells and Disease - PUMPKIN, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg Denmark.
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- Garima Ghale
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Mads P. Møller
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Christina Lohr
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Andreas L. Christensen
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Bo H. Justesen
- Centre for Membrane Pumps in Cells and Disease - PUMPKIN, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg Denmark.
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- Ida L. Jørgensen
- Centre for Membrane Pumps in Cells and Disease - PUMPKIN, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg Denmark.
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- Jürgen Schiller
- Institute of Medical Physics and Biophysics, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
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- Nikos S. Hatzakis
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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- Michael Grabe
- Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA.
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- Thomas Günther Pomorski
- Centre for Membrane Pumps in Cells and Disease - PUMPKIN, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg Denmark.
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- Dimitrios Stamou
- Bionanotecnology and Nanomedicine Laboratory, University of Copenhagen, Copenhagen, Denmark.
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説明
<jats:title>A proton pump in action</jats:title> <jats:p> P-type adenosine triphosphatases (ATPases) use the energy from ATP hydrolysis to pump cations across biological membranes. The electrochemical gradients that are generated control many essential cellular processes. Veshaguri <jats:italic>et al.</jats:italic> incorporated a plant proton pump into vesicles and monitored the dynamics of single pumps. Pumping was stochastically interrupted by long-lived inactive or leaky states. The work reveals how these proton pumps are regulated by a protein domain and by pH gradients. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1469" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad6429">1469</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 351 (6280), 1469-1473, 2016-03-25
American Association for the Advancement of Science (AAAS)
