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Nickel‐Catalyzed Direct Alkylation of Heterocycles with α‐Bromo Carbonyl Compounds: C3‐Selective Functionalization of 2‐Pyridones
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Description
Nickel HAS it: A Ni(cod)2/dppp catalyst system promotes the direct alkylation of electron-rich heterocycles with α-bromo carbonyl compounds and involves an alkyl radical intermediate (see scheme; cod = 1,5-cyclooctadiene, dppp = 1,3-bis(diphenylphosphino)propane). This homolytic radical aromatic substitution (HAS)-type reaction enables the C3-selective direct functionalization of 2-pyridones.
Journal
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- Chemistry – A European Journal
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Chemistry – A European Journal 19 (24), 7691-7695, 2013-05-02
Wiley
