Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia

DOI Web Site Web Site PubMed 被引用文献2件 参考文献32件 オープンアクセス
  • Lika'a Fasih Y. Al-Kzayer
    Department of Pediatrics; Shinshu University School of Medicine; Matsumoto, Nagano Japan
  • Kazuo Sakashita
    Department of Pediatrics; Shinshu University School of Medicine; Matsumoto, Nagano Japan
  • Mazin Faisal Al-Jadiry
    Department of Pediatrics; College of Medicine; Baghdad University; Baghdad Medical City Baghdad Iraq
  • Salma Abbas Al-Hadad
    Department of Pediatrics; College of Medicine; Baghdad University; Baghdad Medical City Baghdad Iraq
  • Hasanein Habeeb Ghali
    Department of Pediatrics; College of Medicine; Baghdad University; Baghdad Medical City Baghdad Iraq
  • Le T.N. Uyen
    Department of Pediatrics; Shinshu University School of Medicine; Matsumoto, Nagano Japan
  • Tingting Liu
    Department of Pediatrics; Shinshu University School of Medicine; Matsumoto, Nagano Japan
  • Kazuyuki Matsuda
    Department of Laboratory Medicine; Shinshu University Hospital; Matsumoto Nagano Japan
  • Jaafar M.H. Abdulkadhim
    Department of Pediatric Oncology; Central Teaching Hospital for Children; Baghdad Iraq
  • Tariq Abadi Al-Shujairi
    Department of Pediatric Oncology; Central Teaching Hospital for Children; Baghdad Iraq
  • Zead Ismael I.K. Matti
    Department of Pediatric Oncology; Central Teaching Hospital for Children; Baghdad Iraq
  • Maher A. Sughayer
    Department of Pathology; King Hussein Cancer Center; Amman Jordan
  • Rawad Rihani
    Department of Pediatrics; King Hussein Cancer Center; Amman Jordan
  • Faris F. Madanat
    Department of Pediatrics; King Hussein Cancer Center; Amman Jordan
  • Toshi Inoshita
    Japan Iraq Medical Network; Tokyo Japan
  • Minoru Kamata
    Japan Chernobyl Foundation; Matsumoto; Nagano Japan
  • Kenichi Koike
    Department of Pediatrics; Shinshu University School of Medicine; Matsumoto, Nagano Japan

書誌事項

タイトル別名
  • RAS Mutations in Arab Pediatric Acute Leukemia
公開日
2015-07-29
資源種別
journal article
権利情報
  • http://doi.wiley.com/10.1002/tdm_license_1.1
DOI
  • 10.1002/pbc.25683
公開者
Wiley

この論文をさがす

説明

KRAS and NRAS gene mutations are frequently observed in childhood leukemia. The objective of this study was to determine the frequency of RAS mutations and the association between RAS mutations and other genetic aberrations in Arab Asian children with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML).Diagnostic samples of 485 patients (<18 years) with acute leukemia from Iraq and Jordan were obtained, using Flinders Technology Associates filter papers. Polymerase chain reaction and direct sequencing were performed in Japan.RAS mutations were detected in 86/318 (27%) of ALL cases and 35/167 (21%) of AML cases. The frequency of NRAS mutation was similar to that of KRAS mutation in ALL. Two RAS mutations were detected in nine patients. Among 264 Iraqi patients with ALL, RAS mutation was significantly associated with lower initial white blood cell count. Of 57 patients with chimeric transcripts, only two patients with either TEL-AML1 or E2A-PBX1 had KRAS mutation. The frequency of NRAS mutation was four times higher than that of KRAS mutation in AML. FAB-M4 and M5 subsets were associated with RAS mutation. Among 134 Iraqi patients with AML, 18 patients had RAS mutations and other genetic aberrations. In particular, 9 of 25 (36%) with MLL-rearrangement had RAS mutations.The prevalence of oncogenic RAS mutations was higher among Arab Asian children than in other countries. RAS mutations in AML were found to coexist with other genetic aberrations, particularly MLL rearrangement.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (32)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ