Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond
書誌事項
- 公開日
- 2013-01
- 資源種別
- journal article
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.bbagrm.2012.11.007
- 公開者
- Elsevier BV
この論文をさがす
説明
DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) were originally identified as factors responsible for transcriptional inhibition by 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (DRB) and were later found to control transcription elongation, together with P-TEFb, at the promoter-proximal region. Although there is ample evidence that these factors play roles throughout the genome, other data also suggest gene- or tissue-specific roles for these factors. In this review, we discuss how these apparently conflicting data can be reconciled. In light of recent findings, we also discuss the detailed mechanism by which these factors control the elongation process at the molecular level. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
収録刊行物
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- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
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Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829 (1), 98-104, 2013-01
Elsevier BV