A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Kouya Shiraishi, Hideo Kunitoh, Yataro Daigo, Atsushi Takahashi, Koichi Goto, Hiromi Sakamoto, Sumiko Ohnami, Yoko Shimada, Kyota Ashikawa, Akira Saito, Shun-ichi Watanabe, Koji Tsuta, Naoyuki Kamatani, Teruhiko Yoshida, Yusuke Nakamura, Jun Yokota, Michiaki Kubo, Takashi Kohno

doi:10.1038/ng.2353

Description

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P(combined) = 2.8 × 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P(combined) = 6.9 × 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P(combined) = 7.4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

Journal

Nature Genetics

Nature Genetics 44 (8), 900-903, 2012-07-15

Springer Science and Business Media LLC

Keywords

Details 詳細情報について

CRID: 1360002216806309248

DOI: 10.1038/ng.2353

ISSN: 15461718; 10614036; http://id.crossref.org/issn/10614036

PubMed: 22797724

Web Site: http://www.nature.com/articles/ng.2353.pdf; http://www.nature.com/articles/ng.2353

Data Source

Crossref
KAKEN
OpenAIRE

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