Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
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- Masanori Ono
- Departments of aObstetrics and Gynecology and
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- Ping Yin
- Departments of aObstetrics and Gynecology and
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- Antonia Navarro
- Departments of aObstetrics and Gynecology and
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- Molly B. Moravek
- Departments of aObstetrics and Gynecology and
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- John S. Coon
- Departments of aObstetrics and Gynecology and
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- Stacy A. Druschitz
- Departments of aObstetrics and Gynecology and
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- Vanida Ann Serna
- Departments of aObstetrics and Gynecology and
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- Wenan Qiang
- Departments of aObstetrics and Gynecology and
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- David C. Brooks
- Departments of aObstetrics and Gynecology and
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- Saurabh S. Malpani
- Departments of aObstetrics and Gynecology and
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- Jiajia Ma
- Departments of aObstetrics and Gynecology and
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- Cihangir Mutlu Ercan
- Departments of aObstetrics and Gynecology and
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- Navdha Mittal
- Departments of aObstetrics and Gynecology and
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- Diana Monsivais
- Departments of aObstetrics and Gynecology and
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- Matthew T. Dyson
- Departments of aObstetrics and Gynecology and
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- Alex Yemelyanov
- Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611; and
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- Tetsuo Maruyama
- Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan
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- Debabrata Chakravarti
- Departments of aObstetrics and Gynecology and
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- J. Julie Kim
- Departments of aObstetrics and Gynecology and
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- Takeshi Kurita
- Departments of aObstetrics and Gynecology and
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- Cara J. Gottardi
- Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611; and
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- Serdar E. Bulun
- Departments of aObstetrics and Gynecology and
Description
<jats:title>Significance</jats:title> <jats:p>Stem cells and the ovarian steroids estrogen and progesterone are essential for leiomyoma tissue growth. The underlying mechanisms are unknown, particularly because leiomyoma stem cells are deficient in estrogen and progesterone receptors. Expression of these receptors is much higher in surrounding mature myometrial or leiomyoma smooth muscle cells. Here, we demonstrate that wingless-type (WNT) acts as a paracrine signal from estrogen/progesterone receptor-rich mature cells to activate the canonical β-catenin pathway in leiomyoma stem cells. Our findings suggest a paracrine role for the canonical WNT pathway in the growth of leiomyoma tumor.</jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 110 (42), 17053-17058, 2013-09-30
Proceedings of the National Academy of Sciences
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Details 詳細情報について
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- CRID
- 1360002217132801280
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- ISSN
- 10916490
- 00278424
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- Data Source
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- Crossref
- KAKEN
