Early development of circadian rhythmicity in the suprachiamatic nuclei and pineal gland of teleost, flounder (<i>Paralichthys olivaeus</i>), embryos
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- Makoto Mogi
- Laboratory of Marine Life Science and Genetics Graduate School of Agricultural Science Tohoku University Sendai 981‐8555 Japan
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- Susumu Uji
- National Research Institute of Aquaculture Farming Biology Division Fisheries Research Agency 422‐1 Minamiise Watarai Mie 516‐0193 Japan
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- Hayato Yokoi
- Laboratory of Marine Life Science and Genetics Graduate School of Agricultural Science Tohoku University Sendai 981‐8555 Japan
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- Tohru Suzuki
- Laboratory of Marine Life Science and Genetics Graduate School of Agricultural Science Tohoku University Sendai 981‐8555 Japan
書誌事項
- 公開日
- 2015-05-26
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/dgd.12222
- 公開者
- Wiley
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説明
<jats:p>Circadian rhythms enable organisms to coordinate multiple physiological processes and behaviors with the earth's rotation. In mammals, the suprachiasmatic nuclei (SCN), the sole master circadian pacemaker, has entrainment mechanisms that set the circadian rhythm to a 24‐h cycle with photic signals from retina. In contrast, the zebrafish SCN is not a circadian pacemaker, instead the pineal gland (PG) houses the major circadian oscillator. The SCN of flounder larvae, unlike that of zebrafish, however, expresses <jats:italic>per2</jats:italic> with a rhythmicity of daytime/ON and nighttime/OFF. Here, we examined whether the rhythm of <jats:italic>per2</jats:italic> expression in the flounder SCN represents the molecular clock. We also examined early development of the circadian rhythmicity in the SCN and PG. Our three major findings were as follows. First, rhythmic <jats:italic>per2</jats:italic> expression in the SCN was maintained under 24 h dark (DD) conditions, indicating that a molecular clock exists in the flounder SCN. Second, onset of circadian rhythmicity in the SCN preceded that in the PG. Third, both 24 h light (LL) and DD conditions deeply affected the development of circadian rhythmicity in the SCN and PG. This is the first report dealing with the early development of circadian rhythmicity in the SCN in fish.</jats:p>
収録刊行物
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- Development, Growth & Differentiation
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Development, Growth & Differentiation 57 (6), 444-452, 2015-05-26
Wiley