Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

  • Sanjay Premi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Silvia Wallisch
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Camila M. Mano
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Adam B. Weiner
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Antonella Bacchiocchi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan.
  • Etelvino J. H. Bechara
    Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05513-970 SP, Brazil.
  • Ruth Halaban
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Thierry Douki
    INAC/LCIB UMR-E3 CEA-UJF/Commissariat à l’Energie Atomique (CEA), 38054 Grenoble Cedex 9, France.
  • Douglas E. Brash
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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<jats:title>The dark side of melanin exposed</jats:title> <jats:p> Sun worshippers may have more to worry about than the DNA damage that occurs while they're relaxing on the beach. It seems that the DNA photoproducts responsible for cancer-causing mutations in skin cells continue to be generated for hours after sunlight exposure. Premi <jats:italic>et al.</jats:italic> find that a key mediator of this delayed damage is melanin, a pigment thought to protect against cancer (see the Perspective by Taylor). They propose a “chemiexcitation” model in which reactive oxygen and nitrogen species induced by ultraviolet light excite an electron in melanin fragments. This energy is then transferred to DNA, inducing the same damage as ultraviolet light, but in the dark. Conceivably, this energy could be dissipated by adding quenchers to sunscreens. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6224" page="842" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1256022">842</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6224" page="824" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa6578">824</jats:related-article> </jats:p>

収録刊行物

  • Science

    Science 347 (6224), 842-847, 2015-02-20

    American Association for the Advancement of Science (AAAS)

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