Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis
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- Hidenori Matsuzaki
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Megumi Maeda
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Suni Lee
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Yasumitsu Nishimura
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Naoko Kumagai-Takei
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Hiroaki Hayashi
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Shoko Yamamoto
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Tamayo Hatayama
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Yoko Kojima
- Research Center for Asbestos-Related Diseases, Okayama Rosai Hospital, 1-10-25 Chikko-Midorimachi, Minami-Ku, Okayama 7028055, Japan
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- Rika Tabata
- Research Center for Asbestos-Related Diseases, Okayama Rosai Hospital, 1-10-25 Chikko-Midorimachi, Minami-Ku, Okayama 7028055, Japan
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- Takumi Kishimoto
- Research Center for Asbestos-Related Diseases, Okayama Rosai Hospital, 1-10-25 Chikko-Midorimachi, Minami-Ku, Okayama 7028055, Japan
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- Junichi Hiratsuka
- Department of Radiation Oncology, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
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- Takemi Otsuki
- Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan
説明
<jats:p>Asbestos causes lung fibrosis known as asbestosis as well as cancers such as malignant mesothelioma and lung cancer. Asbestos is a mineral silicate containing iron, magnesium, and calcium with a core of SiO<jats:sub>2</jats:sub>. The immunological effect of silica, SiO<jats:sub>2</jats:sub>, involves the dysregulation of autoimmunity because of the complications of autoimmune diseases found in silicosis. Asbestos can therefore cause alteration of immunocompetent cells to result in a decline of tumor immunity. Additionally, due to its physical characteristics, asbestos fibers remain in the lung, regional lymph nodes, and the pleural cavity, particularly at the opening sites of lymphatic vessels. Asbestos can induce chronic inflammation in these areas due to the production of reactive oxygen/nitrogen species. As a consequence, immunocompetent cells can have their cellular and molecular features altered by chronic and recurrent encounters with asbestos fibers, and there may be modification by the surrounding inflammation, all of which eventually lead to decreased tumor immunity. In this paper, the brief results of our investigation regarding reduction of tumor immunity of immunocompetent cells exposed to asbestos<jats:italic>in vitro</jats:italic>are discussed, as are our findings concerned with an investigation of chronic inflammation and analyses of peripheral blood samples derived from patients with pleural plaque and mesothelioma that have been exposed to asbestos.</jats:p>
収録刊行物
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- Journal of Biomedicine and Biotechnology
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Journal of Biomedicine and Biotechnology 2012 1-9, 2012
Hindawi Limited
