[Retracted] Construction of a New In(III)-Based Coordination Polymer for Selective Luminescent Detection of Cr2O72− and Anti-Bacterial Protective Effect on <i>Staphylococcus Aureus</i> Infection after Missed Abortion

DOI PDF 被引用文献2件 参考文献21件
  • Di Wang
    Inner Mongolia University for Nationlities, Tongliao, Inner Mongolia Autonomous Region, P. R. China
  • Bin Zhang
    Inner Mongolia University for Nationlities, Tongliao, Inner Mongolia Autonomous Region, P. R. China
  • Lin-Fen Xu
    Department of Gynaecology, Fujian Medical University, Fuzhou, Fujian, P. R. China
  • Ling-Na Huang
    Department of Gynaecology, Fujian Medical University, Fuzhou, Fujian, P. R. China

この論文をさがす

説明

<jats:title>Abstract</jats:title> <jats:p>A new luminescent In(III)-based coordination polymer with the chemical formula of {[In(ipa)(H2O)](H2O)(CH3CN)2}n (1, H3ipa = 5-hydroxyisophthalate) has been successfully prepared via a solvothermal reaction of H3ipa and In(NO3)3·6H2O in CH3CN and DMF mixed solvent. The strong emission of 1 could be quenched efficiently by trace amounts of Cr2O72−, while other competing analogues show no such quenching effect, indicating complex 1 could be applied as an effective sensor for the detection of Cr2O72− in the solution. To solve the problem of bacterial infection after missed abortion, the protective effect of the compound in vivo was further explored. CFU detection was carried to evaluate the inhibitory effect of compound on bacterial numbers, and then ELISA was conducted to detect the level of IL-18 and IL-1β in the infectious tissues. The pharmacokinetic detection of the compound was also performed in SD rats. The results obtained from molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to NFκB, which might provide potential regulation mechanisms for the compound.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (21)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ