Facile Three-Component Synthesis of Substituted Quinolines Catalyzed by Iridium(III) Complex
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- Takayuki Nakajima
- Department of Applied Chemistry, Graduate School of Science and Engineering, Waseda University
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- Takashi Inada
- Department of Applied Chemistry, Graduate School of Science and Engineering, Waseda University
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- Takeyuki Igarashi
- Department of Applied Chemistry, Graduate School of Science and Engineering, Waseda University
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- Tadashi Sekioka
- Department of Applied Chemistry, Graduate School of Science and Engineering, Waseda University
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- Isao Shimizu
- Department of Applied Chemistry, Graduate School of Science and Engineering, Waseda University
抄録
<jats:title>Abstract</jats:title> <jats:p>A convenient and efficient synthesis of substituted quinolines via a simple one-pot reaction of an aniline, an aromatic aldehyde, and an enolizable aliphatic aldehyde in the presence of the iridium catalyst [IrCl2H(cod)]2 under oxygen as an oxidant was developed. The reaction proceeds with Mannich-type imine formation followed by nucleophilic addition to give β-amino aldehydes. Dehydrative cyclization takes place to give dihydroquinoline, which is then dehydrogenated by aerobic oxidation to give 2-aryl-3-alkylquinolines. Dialkylquinolines were obtained by the reaction with anilines and aliphatic aldehydes in good yields.</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 79 (12), 1941-1949, 2006-12-01
Oxford University Press (OUP)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360002219105126528
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- NII論文ID
- 130004058692
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- ISSN
- 13480634
- 00092673
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- データソース種別
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