Production of Local Acoustic Radiation Force to Constrain Direction of Microcapsules in Flow

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<jats:p> We have ever reported our attempt to control the direction of microcapsules in flow by acoustic radiation force. However, the diameter of capsules was too large to be applied <jats:italic>in vivo</jats:italic>. Furthermore, the acoustic radiation force affected only the focal area because focused ultrasound was used. Thus, we have improved our experiment by using microcapsules as small as blood cells and introducing a plane wave of ultrasound. We prepared an artificial blood vessel including a Y-form bifurcation established in two observation areas. Then, we newly defined the induction index to evaluate the difference in capsule density in two downstream paths. As a result, the optimum angle of ultrasound emission to induct to the desired path was derived. The induction index increased in proportion to the central frequency of ultrasound, which is affected by the aggregation of capsules to receive more acoustic radiation force. </jats:p>

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