Effect of Existence of Red Blood Cells in Trapping Performance of Microbubbles by Acoustic Radiation Force

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<jats:p> We have proposed a method to control microbubbles by making use of acoustic radiation force, which is generated with acoustic propagation, to correspond to therapeutic applications of ultrasound. By preventing bubbles from passing through the desired target area, the local concentration of bubbles can be enhanced. However, we have never experimentally confirmed this phenomenon under <jats:italic>in vivo</jats:italic> conditions or close to those. Thus, we carried out an experiment to evaluate the trapping performance of bubbles using a suspension of red blood cells (RBCs) and an artificial blood vessel. By defining the trapping index to evaluate the amount of trapped microbubbles, we have confirmed that the trapping performance was enhanced according to the concentration of RBCs and the sound pressure, but not according to the central frequency of ultrasound. The results indicate that the existence of RBCs near microbubbles contributed to the increase in the size of aggregations propelled against the vessel wall. </jats:p>

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