Catalytic Asymmetric Hydrogenation of Pyrimidines

DOI Web Site Web Site 4 Citations 61 References

Abstract

<jats:title>Abstract</jats:title><jats:p>The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99 % <jats:italic>ee</jats:italic>) using an iridium catalyst composed of [IrCl(cod)]<jats:sub>2</jats:sub>, a ferrocene‐containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)<jats:sub>3</jats:sub> (cod=1,5‐cyclooctadiene). The chiral catalyst converted various 4‐substituted pyrimidines into chiral 1,4,5,6‐tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.</jats:p>

Journal

Citations (4)*help

See more

References(61)*help

See more

Related Projects

See more

Report a problem

Back to top