Highly Efficient Aerobic Oxidation of Alcohols by Using Less‐Hindered Nitroxyl‐Radical/Copper Catalysis: Optimum Catalyst Combinations and Their Substrate Scope
書誌事項
- 公開日
- 2015-01-23
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/asia.201403245
- 10.1002/chin.201547060
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The oxidation of alcohols into their corresponding carbonyl compounds is one of the most fundamental transformations in organic chemistry. In our recent report, 2‐azaadamantane <jats:italic>N</jats:italic>‐oxyl (AZADO)/copper catalysis promoted the highly chemoselective aerobic oxidation of unprotected amino alcohols into amino carbonyl compounds. Herein, we investigated the extension of the promising AZADO/copper‐catalyzed aerobic oxidation of alcohols to other types of alcohol. During close optimization of the reaction conditions by using various alcohols, we found that the optimum combination of nitroxyl radical, copper salt, and solution concentration was dependent on the type of substrate. Various alcohols, including highly hindered and heteroatom‐rich ones, were efficiently oxidized into their corresponding carbonyl compounds under mild conditions with lower amounts of the catalysts.</jats:p>
収録刊行物
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- Chemistry – An Asian Journal
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Chemistry – An Asian Journal 10 (4), 1004-1009, 2015-01-23
Wiley
