B cells expressing CD11b effectively inhibit CD4+ T‐cell responses and ameliorate experimental autoimmune hepatitis in mice
-
- Xiaoming Liu
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Xuechao Jiang
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Ronghua Liu
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Luman Wang
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Tingting Qian
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Yijie Zheng
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Yuting Deng
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Enyu Huang
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Fengkai Xu
- Department of Thoracic Surgery,The Affiliated Zhongshan Hospital of Fudan University,Shanghai,China
-
- Ji‐Yang Wang
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
-
- Yiwei Chu
- Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China
説明
<jats:p>Increasing evidence in recent years has suggested that B cells act as a crucial regulator in autoimmune diseases. However, little is known about their role in autoimmune hepatitis (AIH) and the underlying regulatory mechanisms. In this study, we show that B cells ameliorated experimental AIH (EAH) by suppressing CD4<jats:sup>+</jats:sup> T‐cell responses and that CD11b expression on B cells was required for the regulatory function of B cells. <jats:italic toggle="yes">In vitro</jats:italic> studies reveal that the suppressive function of CD11b was mediated by the impairment of T‐cell antigen receptor (TCR) signaling transduction and the promotion of TCR down‐regulation. Moreover, we show that the increased CD11b expression on B cells was interleukin (IL)−10 dependent and that additional IL‐10 stimulation promoted CD11b expression on B cells, thereby enhancing B‐cell regulatory effects. <jats:italic toggle="yes">Conclusion</jats:italic>: These findings reveal a previously unrecognized role for CD11b in B‐cell regulatory function and its protective effect on EAH. (H<jats:sc>epatology</jats:sc> 2015;62:1563–1575)</jats:p>
収録刊行物
-
- Hepatology
-
Hepatology 62 (5), 1563-1575, 2015-09-28
Ovid Technologies (Wolters Kluwer Health)
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1360004230127304448
-
- ISSN
- 15273350
- 02709139
-
- データソース種別
-
- Crossref
- KAKEN