Virological and immunological mechanisms in the pathogenesis of human T‐cell leukemia virus type 1

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  • Yorifumi Satou
    Laboratory for Virus Control, Institute for Virus Research Kyoto University Kyoto Japan
  • Masao Matsuoka
    Laboratory for Virus Control, Institute for Virus Research Kyoto University Kyoto Japan

Abstract

<jats:title>SUMMARY</jats:title><jats:p>Human T‐cell leukemia virus type 1 (HTLV‐1) was the first retrovirus shown to cause human disease, such as adult T‐cell leukemia and HTLV‐1 associated myelopathy/tropic spastic paraparesis. HTLV‐1 mainly infects CD4 T cells and deregulates their differentiation, function and homeostasis, which should contribute to the pathogenesis of HTLV‐1, for example, inducing transformation of infected CD4 T cells and chronic inflammatory diseases. Therefore, not only virological approach but also immunological approach regarding CD4 T cells are required to understand how HTLV‐1 causes related human diseases. This review focuses on recent advances in our understanding of the interaction between HTLV‐1 and the main host cell, CD4 T cells, which should provide us some clue to the mechanisms of HTLV‐1 mediated pathogenesis. Copyright © 2013 John Wiley & Sons, Ltd.</jats:p>

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