NAD metabolism and the SLC34 family: evidence for a liver-kidney axis regulating inorganic phosphate
書誌事項
- 公開日
- 2018-09-14
- 資源種別
- journal article
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1007/s00424-018-2204-2
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
The solute carrier 34 (SLC34) family of membrane transporters is a major contributor to Pi homeostasis. Many factors are involved in regulating the SLC34 family. The roles of the bone mineral metabolism factors parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) in Pi homeostasis are well studied. Intracellular Pi is thought to be involved in energy metabolism, such as ATP production. Under certain conditions of altered energy metabolism, plasma Pi concentrations are affected by the regulation of a Pi shift into cells or release from the tissues. We recently investigated the mechanism of hepatectomy-related hypophosphatemia, which is thought to involve an unknown phosphaturic factor. Hepatectomy-related hypophosphatemia is due to impaired nicotinamide adenine dinucleotide (NAD) metabolism through its effects on the SLC34 family in the liver-kidney axis. The oxidized form of NAD, NAD
収録刊行物
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- Pflügers Archiv - European Journal of Physiology
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Pflügers Archiv - European Journal of Physiology 471 (1), 109-122, 2018-09-14
Springer Science and Business Media LLC
