WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3
書誌事項
- 公開日
- 2017-09
- 資源種別
- journal article
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- https://doi.org/10.15223/policy-017
- https://doi.org/10.15223/policy-037
- https://doi.org/10.15223/policy-012
- https://doi.org/10.15223/policy-029
- https://doi.org/10.15223/policy-004
- DOI
-
- 10.1016/j.bbrc.2017.07.121
- 公開者
- Elsevier BV
この論文をさがす
説明
WNK-OSR1/SPAK-NCC signaling cascade is important for regulating salt balance and blood pressure. Activation of WNK-OSR1/SPAK-NaCl cotransporter (NCC) cascade increases sodium reabsorption in the kidney, leading to pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia. It has been previously demonstrated that the amount of phosphorylated and total NCC markedly decreased in WNK4
収録刊行物
-
- Biochemical and Biophysical Research Communications
-
Biochemical and Biophysical Research Communications 491 (3), 727-732, 2017-09
Elsevier BV
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キーワード
- Male
- Mice, Knockout
- Pseudohypoaldosteronism
- Microfilament Proteins
- Mice, Transgenic
- Protein Serine-Threonine Kinases
- Kidney
- Mice, Inbred C57BL
- Minor Histocompatibility Antigens
- Mice
- Structure-Activity Relationship
- WNK Lysine-Deficient Protein Kinase 1
- Mutation
- Animals
- Female
- Adaptor Proteins, Signal Transducing
詳細情報 詳細情報について
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- CRID
- 1360004232001908352
-
- ISSN
- 0006291X
-
- PubMed
- 28743496
-
- 資料種別
- journal article
-
- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
