Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents
書誌事項
- 公開日
- 2010-08
- 資源種別
- journal article
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.bmc.2010.05.075
- 公開者
- Elsevier BV
この論文をさがす
説明
The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers. These synthesized dimers exhibited binding affinity to the N-terminal domain of Hsp90, cytotoxicity, and client degradation activity although these activities were comparative or weak comparable with that of the parent compound.
収録刊行物
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- Bioorganic & Medicinal Chemistry
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Bioorganic & Medicinal Chemistry 18 (15), 5732-5737, 2010-08
Elsevier BV
