Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma
書誌事項
- 公開日
- 2012-10
- 資源種別
- journal article
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
-
- 10.1016/j.canlet.2012.03.042
- 10.1016/j.freeradbiomed.2012.01.018
- 公開者
- Elsevier BV
この論文をさがす
説明
Nasopharyngeal carcinoma (NPC) is endemic in southern China. In a genome-wide screen for genes inactivated by promoter hypermethylation, we identified Ras-related associated with diabetes (RRAD). Expression of RRAD was down-regulated in 83.3% (30/36) of the biopsies from NPC patients. RRAD was aberrantly methylated in 74.3% (26/35) of primary tumors, but not in normal nasopharyngeal epithelium. Ectopic RRAD expression in NPC cell lines inhibited the cell growth, colony formation, and cell migration. These results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development.
収録刊行物
-
- Cancer Letters
-
Cancer Letters 323 (2), 147-154, 2012-10
Elsevier BV
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1360004232029957504
-
- ISSN
- 03043835
- 08915849
-
- Web Site
- https://api.elsevier.com/content/article/PII:S0304383512002340?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0304383512002340?httpAccept=text/plain
- https://api.elsevier.com/content/article/PII:S0891584912000627?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0891584912000627?httpAccept=text/plain
-
- 資料種別
- journal article
-
- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
