Asymmetric Total Synthesis of (−)-Scabronine G via Intramolecular Double Michael Reaction and Prins Cyclization
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- Naoki Kanoh
- Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
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- Kohei Sakanishi
- Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
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- Emiko Iimori
- Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
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- Ken’ichi Nishimura
- Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
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- Yoshiharu Iwabuchi
- Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
書誌事項
- 公開日
- 2011-05-06
- 資源種別
- journal article
- DOI
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- 10.1021/ol200873y
- 公開者
- American Chemical Society (ACS)
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説明
The enantioselective total synthesis of (-)-scabronine G is described. The key features of the present synthesis include the construction of a 5-6 ring system containing two quaternary carbon centers via a diastereoselective intramolecular double Michael reaction and the formation of a seven-membered ring using a Prins cyclization.
収録刊行物
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- Organic Letters
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Organic Letters 13 (11), 2864-2867, 2011-05-06
American Chemical Society (ACS)
