Copper-Catalyzed Regioselective Trifluoromethylthiolation of Pyrroles by Trifluoromethanesulfonyl Hypervalent Iodonium Ylide

  • Zhongyan Huang
    Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya466-8555, Japan
  • Yu-Dong Yang
    Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya466-8555, Japan
  • Etsuko Tokunaga
    Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya466-8555, Japan
  • Norio Shibata
    Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya466-8555, Japan

書誌事項

公開日
2015-02-16
資源種別
journal article
DOI
  • 10.1021/ol503616y
  • 10.1002/chin.201529150
公開者
American Chemical Society (ACS)

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説明

The copper-catalyzed trifluoromethylthiolation of pyrroles with a trifluoromethanesulfonyl hypervalent iodonium ylide under mild conditions has been achieved. A broad set of pyrroles could be transformed to the corresponding products in moderate to excellent yields. The reaction mechanism is hypothesized.

収録刊行物

  • Organic Letters

    Organic Letters 17 (5), 1094-1097, 2015-02-16

    American Chemical Society (ACS)

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