The p75 receptor mediates axon growth inhibition through an association with PIR-B
書誌事項
- 公開日
- 2011-09-01
- 資源種別
- journal article
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1038/cddis.2011.85
- 公開者
- Springer Science and Business Media LLC
説明
The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand binding. In addition, p75 was required for activation of Src homology 2-containing protein tyrosine phosphatase (SHP), which is induced by MAG binding to PIR-B. Mice carrying a mutation in the p75 gene showed promotion of axonal regeneration after optic nerve injury. Thus, our results indicate that p75 has a critical role in axon growth inhibition in specific neuronal tracts.
収録刊行物
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- Cell Death & Disease
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Cell Death & Disease 2 (9), e198-e198, 2011-09-01
Springer Science and Business Media LLC
