書誌事項
- 公開日
- 2013-02-06
- 資源種別
- journal article
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1038/ja.2012.125
- 公開者
- Springer Science and Business Media LLC
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説明
The stereoselective total synthesis of garsubellin A is described. The total synthesis was achieved through the stereoselective construction of a bicyclo[3.3.1]nonane derivative via a three-step sequence: intramolecular cyclopropanation, formation of a germinal dimethyl group, and regioselective ring opening of cyclopropane. To complete the total synthesis of garsubellin A, chemo- and stereoselective hydrogenation to generate the C8 stereogenic center is followed by the formation of the fused tetrahydrofuran ring by a regioselective epoxide-opening reaction with C3 ketone, and finally cross metathesis to construct two prenyl groups.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 66 (3), 141-145, 2013-02-06
Springer Science and Business Media LLC
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詳細情報 詳細情報について
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- CRID
- 1360004233408656128
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- NII論文ID
- 10031163113
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- NII書誌ID
- AA0069330X
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- ISSN
- 18811469
- 00218820
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- PubMed
- 23385132
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- 資料種別
- journal article
-
- データソース種別
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- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
