Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task
書誌事項
- 公開日
- 2014-06-01
- 資源種別
- journal article
- 権利情報
-
- http://www.springer.com/tdm
- DOI
-
- 10.1038/nn.3739
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
The primary motor cortex (M1) possesses two intermediate layers upstream of the motor-output layer: layer 2/3 (L2/3) and layer 5a (L5a). Although repetitive training often improves motor performance and movement coding by M1 neuronal ensembles, it is unclear how neuronal activities in L2/3 and L5a are reorganized during motor task learning. We conducted two-photon calcium imaging in mouse M1 during 14 training sessions of a self-initiated lever-pull task. In L2/3, the accuracy of neuronal ensemble prediction of lever trajectory remained unchanged globally, with a subset of individual neurons retaining high prediction accuracy throughout the training period. However, in L5a, the ensemble prediction accuracy steadily improved, and one-third of neurons, including subcortical projection neurons, evolved to contribute substantially to ensemble prediction in the late stage of learning. The L2/3 network may represent coordination of signals from other areas throughout learning, whereas L5a may participate in the evolving network representing well-learned movements.
収録刊行物
-
- Nature Neuroscience
-
Nature Neuroscience 17 (7), 987-994, 2014-06-01
Springer Science and Business Media LLC
- Tweet
キーワード
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Male
- Motor Neurons
- Neurons
- Patch-Clamp Techniques
- Genetic Vectors
- Motor Cortex
- Neuroimaging
- Dependovirus
- Efferent Pathways
- Mice, Inbred C57BL
- Mice
- Reward
- Motor Skills
- Forelimb
- Image Processing, Computer-Assisted
- Animals
- Conditioning, Operant
- Learning
- Psychomotor Performance
詳細情報 詳細情報について
-
- CRID
- 1360004233441570816
-
- DOI
- 10.1038/nn.3739
-
- ISSN
- 15461726
- 10976256
-
- PubMed
- 24880217
-
- 資料種別
- journal article
-
- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE