Octacosanol restores stress-affected sleep in mice by alleviating stress

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書誌事項

公開日
2017-08
資源種別
journal article
権利情報
  • © The Author(s) 2017
  • This article is licensed under a Creative Commons Attribution 4.0 International License which permits use sharing adaptation distribution and reproduction in any medium or format as long as you give appropriate credit to the original author(s) and the source provide a link to the Cre- ative Commons license and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per- mitted by statutory regulation or exceeds the permitted use you will need to obtain permission directly from the copyright holder. To view a copy of this license visit http://creativecommons.org/licenses/by/4.0/ .
DOI
  • 10.1038/s41598-017-08874-2
公開者
Nature Publishing Group

説明

<jats:title>Abstract</jats:title><jats:p>Octacosanol, a component of various food materials, possesses prominent biological activities and functions. It fights against cellular stress by increasing glutathione level and thus scavenging oxygen reactive species. However, its anti-stress activity and role in sleep induction remained elusive. We hypothesize that octacosanol can restore stress-affected sleep by mitigating stress. Cage change strategy was used to induce mild stress and sleep disturbance in mice, and effects of octacosanol administration on amount of sleep and stress were investigated. Results showed that octacosanol did not change rapid eye movement (REM) or non-REM (NREM) sleep compared to vehicle in normal mice. However, in cage change experiment, octacosanol induces significant increase in NREM sleep at doses of 100 and 200 mg/kg (75.7 ± 14.9 and 82.7 ± 9.3 min/5 h) compared to vehicle (21.2 ± 5.1 min/5 h), and decreased sleep latency. Octacosanol induced sleep by increasing number of sleep episodes and decreasing wake episode duration. Plasma corticosterone levels were significantly reduced after octacosanol (200 mg/kg) administration, suggesting a decrease in stress level. Octacosanol-induced changes in sleep-wake parameters in stressed-mice were comparable to the values in normal mice. Together, these data clearly showed that, though octacosanol does not alter normal sleep, it clearly alleviates stress and restore stress-affected sleep.</jats:p>

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