Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study
書誌事項
- 公開日
- 2016-02-05
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0
- https://creativecommons.org/licenses/by/4.0
- DOI
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- 10.1038/srep20074
- 公開者
- Springer Science and Business Media LLC
説明
<jats:title>Abstract</jats:title><jats:p>Oral infectious diseases are epidemiologically associated with stroke. We previously showed that oral <jats:italic>Streptococcus mutans</jats:italic> with the <jats:italic>cnm</jats:italic> gene encoding a collagen-binding Cnm protein induced intracerebral hemorrhage (ICH) experimentally and was also associated with cerebral microbleeds (CMBs) in our population-based cohort study. We therefore investigated the roles of <jats:italic>cnm</jats:italic>-positive <jats:italic>Streptococcus mutans</jats:italic> in this single hospital-based, observational study that enrolled 100 acute stroke subjects. The <jats:italic>cnm</jats:italic> gene in <jats:italic>Streptococcus mutans</jats:italic> isolated from saliva was screened using PCR techniques and its collagen-binding activities examined. CMBs were evaluated on T2* gradient-recalled echo MRI. One subject withdrew informed consent and 99 subjects (63 males) were analyzed, consisting of 67 subjects with ischemic stroke, 5 with transient ischemic attack and 27 with ICH. Eleven cases showed <jats:italic>Streptococcus mutans</jats:italic> strains positive for <jats:italic>cnm</jats:italic>. The presence of <jats:italic>cnm</jats:italic>-positive <jats:italic>Streptococcus mutans</jats:italic> was significantly associated with ICH [OR vs. ischemic stroke, 4.5; 95% CI, 1.17–19.1] and increased number of deep CMBs [median (IQR), 3 (2–9) vs. 0 (0–1), p = 0.0002]. In subjects positive for <jats:italic>Streptococcus mutans</jats:italic>, collagen binding activity was positively correlated with the number of deep CMBs (R<jats:sup>2</jats:sup> = 0.405; p < 0.0001). These results provide further evidence for the key role of oral health in stroke.</jats:p>
収録刊行物
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- Scientific Reports
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Scientific Reports 6 (1), 20074-, 2016-02-05
Springer Science and Business Media LLC