Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period

DOI DOI DOI HANDLE PDF ほか2件をすべて表示 一部だけ表示 被引用文献1件 参考文献42件 オープンアクセス

書誌事項

公開日
2016-08-25
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0
  • https://creativecommons.org/licenses/by/4.0
DOI
  • 10.1038/srep32159
  • 10.60692/dt0t2-cxm80
  • 10.60692/55xrq-ffv02
公開者
Springer Science and Business Media LLC

説明

<jats:title>Abstract</jats:title> <jats:p> During pregnancy a variety of immunological changes occur to accommodate the fetus. It is unknown whether these changes continue to affect humoral immunity postpartum or how quickly they resolve. IgG levels were measured to <jats:italic>P. falciparum</jats:italic> and <jats:italic>P. vivax</jats:italic> antigens in 201 postpartum and 201 controls over 12 weeks. Linear mixed-effects models assessed antibody maintenance over time and the effect of microscopically confirmed <jats:italic>Plasmodium</jats:italic> spp. infection on antibody levels, and whether this was different in postpartum women compared with control women. Postpartum women had reduced <jats:italic>Plasmodium</jats:italic> spp. antibody levels compared to controls at baseline. Over 12 weeks, mean antibody levels in postpartum women increased to levels observed in control women. Microscopically confirmed <jats:italic>P. falciparum</jats:italic> and <jats:italic>P. vivax</jats:italic> infections during follow-up were associated with an increase in species-specific antibodies with similar magnitudes of boosting observed in postpartum and control women. Antibodies specific for pregnancy-associated, VAR2CSA-expressing parasites did not rapidly decline postpartum and did not boost in response to infection in either postpartum or control women. After pregnancy, levels of malaria-specific antibodies were reduced, but recovered to levels seen in control women. There was no evidence of an impaired ability to mount a boosting response in postpartum women. </jats:p>

収録刊行物

  • Scientific Reports

    Scientific Reports 6 (1), 32159-, 2016-08-25

    Springer Science and Business Media LLC

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