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Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses
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- Yoshihiro Sohtome
- Synthetic Organic Chemistry Laboratory
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- Tadahiro Shimazu
- Cellular Memory Laboratory
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- Joaquin Barjau
- Synthetic Organic Chemistry Laboratory
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- Shinya Fujishiro
- Synthetic Organic Chemistry Laboratory
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- Mai Akakabe
- Synthetic Organic Chemistry Laboratory
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- Naoki Terayama
- Synthetic Organic Chemistry Laboratory
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- Kosuke Dodo
- Synthetic Organic Chemistry Laboratory
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- Akihiro Ito
- RIKEN Center for Sustainable Resource Science, RIKEN
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- Minoru Yoshida
- RIKEN Center for Sustainable Resource Science, RIKEN
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- Yoichi Shinkai
- Cellular Memory Laboratory
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- Mikiko Sodeoka
- Synthetic Organic Chemistry Laboratory
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Description
<p>We present a chemical methylome analysis to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases.</p>
Journal
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- Chemical Communications
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Chemical Communications 54 (66), 9202-9205, 2018
Royal Society of Chemistry (RSC)
