Structural basis for the recognition–evasion arms race between <i>Tomato mosaic virus</i> and the resistance gene <i>Tm-1</i>
-
- Kazuhiro Ishibashi
- Plant-Microbe Interactions Research Unit and
-
- Yuichiro Kezuka
- Department of Structural Biology, School of Pharmacy, Iwate Medical University, Yahaba, Iwate 020-0023, Japan; and
-
- Chihoko Kobayashi
- Biomolecular Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan;
-
- Masahiko Kato
- Biomolecular Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan;
-
- Tsuyoshi Inoue
- Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
-
- Takamasa Nonaka
- Department of Structural Biology, School of Pharmacy, Iwate Medical University, Yahaba, Iwate 020-0023, Japan; and
-
- Masayuki Ishikawa
- Plant-Microbe Interactions Research Unit and
-
- Hiroyoshi Matsumura
- Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
-
- Etsuko Katoh
- Biomolecular Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan;
書誌事項
- 公開日
- 2014-08-04
- 資源種別
- journal article
- DOI
-
- 10.1073/pnas.1407888111
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>The Red Queen hypothesis proposes that host defense genes evolve to counter the adverse effects of rapidly evolving invasive viruses. Although 3D structures of host–viral protein complexes have provided great insights into the molecular conflicts between them, a single structure represents only an evolutionary snapshot. Here we present the atomic details of the step-by-step arms race between tomato mosaic virus replication protein and the host inhibitor protein Tm-1, in which host recognition of a viral molecule, viral adaptive evasion of the recognition, host counteradaptation, and viral counter-counteradaptation are depicted by determination of the complex structures of Tm-1 variants and the viral protein and by biochemical analyses and molecular dynamics simulations of the interactions between these proteins.</jats:p>
収録刊行物
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 111 (33), E3486-, 2014-08-04
Proceedings of the National Academy of Sciences